Family history of sudden cardiac death among victims of sudden death in yazd, iran

Document Type : original articles

Authors

1 Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Tehran University of Medical Sciences, Ziaeian Hospital, Tehran,Iran

3 Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran

Abstract

Objectives: A positive family history of Sudden Cardiac Death (SCD) is an independent risk factor for mortality. This study aimed to determine the prevalence of a positive family history of SCD and its associated risk factors among victims of sudden death in Yazd.
 
Methods: This cross-sectional study investigated SCD cases in Yazd, Iran, in 2011. The study included victims who were aged 20 years or older, and the cause of death was the cardiac arrest within one hour of symptom onset. The data obtained from families of SCD victims through verbal autopsy interviews.
 
Results: A total of 317 cases of SCD occurred among victims, resulting in an incidence rate of 139.4 per 100,000 population 26.2% had a positive family history of SCD, with a mean age of 60.4 ± 12.3 years. Individuals with a positive family history of SCD had a significantly younger mean age at the time of death (60.9 ± 12.3 vs. 66.9 ± 16.5 years, P = 0.018). The prevalence of diabetes mellitus (odds ratio 1.43, CI 95% = 1.03–1.99, P = 0.042), dyslipidemia (odds ratio 1.47, CI 95% = 1.07–2.1, P = 0.038), chronic coronary artery disease (P =0.027), and revascularization (P = 0.049) had a significant association with positive family history of SCD.
 
Conclusions: This study highlights the importance of assessing family history as a risk factor for SCD, along with other risk factors such as diabetes, dyslipidemia, and chronic coronary artery disease.

Keywords

References

1.Adabag AS, Luepker RV, Roger VL, et al. Sudden cardiac death: epidemiology and risk factors Nat Rev Cardiol. 2010;7(4):216-25.
2.Zheng ZJ, Croft JB, Giles WH, et al. Sudden cardiac death in the united states, 1989 to 1998. Circulation.2001; 104(18):2158-2163.
3.Votýpka P, Krebsová A, Norambuena-Poustková P, et al. Post-mortem genetic testing in sudden cardiac death and genetic screening of relatives at risk: lessons learned from a Czech pilot multidisciplinary study. Int J Legal Med.2023;137(6):1787-1801.
4.Narayan SM, Wang PJ, Daubert JP. New concepts in sudden cardiac arrest to address an intractable epidemic: JACC state-of-the-art review. J Am Coll Cardiol. 2019;73(1):70-88.
5.Wong CX, Brown A, Lau DH, et al. Epidemiology of sudden cardiac death: global and regional perspectives.Heart Lung Circ.2019;28(1):6-14.
6.Davies M J. Anatomic features in victims of sudden coronary death.Coronary artery pathology. Circulation. 1992;85(1):I19-24.
7.de Vreede-Swagemakers JJ, Gorgels AP, Dubois-Arbouw WI, et al.Out-of-hospital cardiac arrest in the 1990s: a population-based study in the Maastricht area on incidence, characteristics and survival. J Am Coll Cardiol.1997;30(6):1500-1505.
8.Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics-2013 update: a report from the American Heart Association.Circulation. 2013;127(1):e6-e245.
9.Jouven X, Desnos M, Guerot C, et al. Predicting sudden death in the population: the Paris Prospective Study I. Circulation.1999;99(15):1978-1983.
10.Ali AN, Abdeltawab HA, Eldamanhoury H, et al. Risk factors of sudden cardiac death in Egyptian patients younger than 40 years. Egypt Heart J.2023;75(1):45.
11.Khosravi A, Taylor R, Naghavi M, et al. Mortality in the islamic republic of Iran, 1964-2004. Bull WHO. 2007; 85(8):607-614.
12.Chugh SS, Jui J, Gunson K, et al.Current burden of sudden cardiac death: multiple source surveillance versus retrospective death certificate- based review in a large US community.J Am Coll Cardiol. 2004; 44(6):1268-75.
13.Hua W, Zhang LF, Wu YF, et al. Incidence of Sudden Cardiac Death in China: analysis of 4 regional populations. J Am Coll Cardiol. 2009;54(12):1110-8.
14.Tokashiki T, Muratani A, Kimura Y, et al. Sudden death in the general population in Okinawa: incidence and causes of death. Jpn Circ J.1999;63(1):37-42.
15.Patel M A, Malhotra A, Mpondo FHM, et al. Sudden cardiac death in the adolescent population: a narrative review. Egypt J Intern Med. 2023;35(1):36.
16.Dalgaard CV, Hansen BL, Jacobsen EM, et al. Sudden unexplained death versus nonautopsied possible sudden cardiac death: Findings in relatives. J Cardiovasc Electrophysiol. 2022; 33(2):254-261.
17.Ferrero Miliani L, Holst AG, Pehrson S, et al. Strategy for clinical evaluation and screening of sudden cardiac death relatives. Fundam Clin Pharmacol. 2010;24(5): 619-635.
18.Myers RH, Kiely DK, Cupples LA, et al. Parental history is an independent risk factor for  coronary artery disease: the Framingham Study. Am Heart J. 1990;120(4):963-969.
19.Podrid PJ . Overview of sudden cardiac arrest and sudden cardiac death. UpToDate. 2017; 1-50.
20.Spoon DB, Psaltis PJ , Singh M, et al. Trends in cause of death after percutaneous coronar intervention. Circulation. 2014;129(12):1286-94.
21.Friedlander Y, Siscovick DS, Weinmann S, et al. Family history as a risk factor for primary cardiac arrest.Circulation.1998; 97(2):155-160.
22.Milano A, Blom MT, Lodder EM, et al. Sudden cardiac arrest and rare genetic variants in the community. Circ Cardiovasc Genet. 2016; 9(2):147-53.
23.Chugh SS, Reinier K, Teodorescu C , et al. Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis.2008;51(3):213-28.
24.Kaikkonen KS, Kortelainen ML, Linna E, et al. Family history and the risk of sudden cardiac death as a manifestation of an acute coronary event. Circulation. 2006;114(14):1462-1467.
25.Hamid L, Abdelfattah A, Hussien K, et al. Screening general population for family history of sudden cardiac death unmasks high risk individuals as potential victims (pilot study). E J C CM. 2018; 6(1):9-16.
26.Webster G, Olson R, Schoppen ZJ, et al.Cardiac Evaluation of Children With a Family History of Sudden Death. J Am Coll Cardiol. 2019;74(6):759-770.
27.Tan BY, Judge DP. A clinical approach to a family history of sudden death. Circ Cardiovasc Genet. 2012;5(6):697-705.
28.Tomaske M, Keller D I, Bauersfeld U.Sudden cardiac death: clinical evaluation of paediatric   family members. Europace. 2011;13(3):421-426.
29.Rao MP, Al-Khatib SM, Pokorney SD, et al. Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting: Results From the STICH Randomized Clinical Trial (Surgical Treatment for Ischemic Heart Failure).Circulation.2017;135(12):1136-1144.
Cardiovascular Biomedicine
Volume 3, Issue 2
December 2023
Pages 7-12

Files

History

  • Receive Date: 09 January 2024
  • Revise Date: 09 March 2024
  • Accept Date: 12 March 2024
  • First Publish Date: 12 March 2024

Share

How to cite

Statistics